MABF841
MilliporeSigma™ Mouse anti-FCGR2A/C, Clone: 11B6,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABF841-Each-of-1 | In Stock | ₹ 38,042.16 |
MABF841 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,042.16
GST (18%): ₹ 6,847.589
Total Price: ₹ 44,889.749
Antigen
FCGR2A/C
Classification
Monoclonal
Formulation
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
CD32; FCG2; FCGR2A; FCGR2A1; FCGR2B; FCGR2C; IGFR2
Immunogen
Linear peptide corresponding to a cytoplasmic domain sequence identical in human FcγRIIa and FcγRIIc.
Quantity
100 μg
Research Discipline
Inflammation and Immunology
Gene ID (Entrez)
NP_001129691.1; NP_963857.3
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
Isotype
IgG1 κ
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone
11B6
Gene Accession No.
P12318; P31995
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Purified
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Description
- Specifically detects FCGR2A/C clone: 11B6 in Human samples, and it is validated for Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blotting FcγRI/CD64, FcγRII/CD32, FcγRIII/CD16, and FcγRIV/CD16-2 represent the four known classes of IgG Fc receptors (FcγRs)
- FcγRII, FcγRIII, and FcγRIV are low-affinity receptors for monomeric IgG, whereas FcγRI is the only high-affinity FcγR
- FcγRs play important roles in inflammatory cell activation, clearance, presentation of Ag, and maintenance of IgG homeostasis
- In addition to binding immune complex (IC), FcγRs have been shown to bind non-IgG ligands
- For example, FcγRII is shown to bind oxLDL, while FcγRIII binding to an E
- coli component is reported to negatively regulate the function of macrophage receptor with collagenous structure (MARCO)
- FcyRII activation is also reported to transduce a negative regulatory signal against CD38 cross-linking-induced proliferation of resting mature B cells
- Low affinity immunoglobulin gamma Fc region receptor II-a/b/c (IgG Fc receptor II-a/-b/-c, CDw32, Fc-gamma RII-a/-b/-c, Fc-gamma-RIIa/b/c, FcRII-a/-b/-c, CD32) are encoded by the FCGR2A/B/C (CD32, FCG2, IGFR2) genes in human (UniProt P12318, P31994, P31995; Gene ID 2212, 2213, 9103)
- The FcγRIIs encoded by the three genes are highly conserved in their extracellular portion, with significant variation in the transmembrane and intracellular regions
- All three types of transcripts alternative splicing to generate additional isoforms.