MABT323MI
MilliporeSigma™ Mouse anti-CEACAM6, Clone: 1H7-4B,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABT323MI-Each-of-1 | In Stock | ₹ 42,114.80 |
MABT323MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,114.80
GST (18%): ₹ 7,580.664
Total Price: ₹ 49,695.464
Antigen
CEACAM6
Classification
Monoclonal
Formulation
Purified mouse monoclonal IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
CEACAM6; NCA
Immunogen
Recombinant protein corresponding to the extracellular domain of human CEACAM6.
Quantity
100 μg
Research Discipline
Cell Structure
Gene ID (Entrez)
NP_002474
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
Isotype
IgG1 κ
Applications
ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone
1H7-4B
Gene Accession No.
P40199
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Purified
Related Products
Description
- Specifically detects CEACAM6 clone: 1H7-4B in Human samples, and it is validated for ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blotting The carcinoembryonic antigen- (CEA-) related cell adhesion molecules (CEACAMs) constitute a 12-member subgroup of the CEA family of immunoglobulin-related proteins first described in 1965 (PMID 4953873)
- CEACAMs are reported to participate in diverse physiological processes, including cell adhesion, differentiation, proliferation, and survival, as well as in carcinogenesis and bacterial pathogenesis
- CEACAM molecules from neighbouring cells can interact via their respective extracellular N-terminal IgV-like domain and mediate cell-cell adhesion through trans-oligomerization
- CEACAM molecules within the same cell can also undergo transmembrane domain-mediated cis-oligomerization, an event important for sustaining downstream cellular signaling
- Athough CEACAM1 is shown to utilize its cytoplasmic domain for transducing cellular signaling, not all CEACAM members are expressed with a significant cytoplasmic domain, and others (CEACAM5/6/7/8) are GPI-anchored without even a transmembrane domain
- (PMID 4735478)
- Human CEACAM6 (also known as CD66c, Non-specific crossreacting antigen, Normal cross-reacting antigen; UniProt P40199) is encoded by the CEACAM6 (or CEAL & NCA) gene (NCBI Gene ID 4680)
- It is a GPI-anchored CEACAM with three extracellular Ig domains
- Clone 1H7-4B does not cross-react with human CEACAM1/3/4/5/7/8, rat CECAM1, or mouse CEACAM1/2.