MilliporeSigma™ anti-TRPM2 Clone: 9D8.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABN769MI-Each-of-1 | In Stock | ₹ 37,825.00 |
MABN769MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,825.00
GST (18%): ₹ 6,808.50
Total Price: ₹ 44,633.50
Antigen
TRPM2
Classification
Monoclonal
Conjugate
Unconjugated
Gene Accession No.
O94759
Host Species
Mouse
Purification Method
Unpurified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Expected to react with all three spliced isoforms reported by UniProt (O94759).
Content And Storage
-20°C for one year from date of shipment; Upon first thaw and prior to removing the cap centrifuge the vial and gently mix the solution; Aliquot into microcentrifuge tubes and store at −20°C; Avoid repeated freeze/thaw cycles
Isotype
IgG2a κ
Applications
Western Blot
Clone
9D8.1
Formulation
Mouse monoclonal IgG2aκ in supernatant without preservatives.
Gene Symbols
TRPM2, EREG1, KNP3, LTRPC2, TRPC7, NUDT9H, NUDT9L1
Immunogen
GST-tagged recombinant protein corresponding to the N-terminal cytoplasmic domain of human TRPM2.
Quantity
100 μL
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_003298
Target Species
Rat
Form
Supernatant
Related Products
Description
- Specifically detects TRPM2 Clone: 9D8.1 in Rat samples, and it is validated for Western Blotting Transient receptor potential cation channel subfamilyM member 2 (EC 3.6.1.13; UniProt O94759; also known as Estrogen-responsive element-associated gene 1 protein, Long transient receptor potential channel 2, LTrpC-2, LTrpC2, Transient receptor potential channel 7, TrpC7) is encoded by the TRPM2 (also known as EREG1, KNP3, LTRPC2, TRPC7, NUDT9H, NUDT9L1) gene (Gene ID 7226) in human
- The human TRPM2 is an 1,503-amino acid, six-transmembrane protein with both N- and C-termini exposed intracellularly
- TRPM2 contains a pore-forming loop domain located between the fifth and sixth transmembrane region
- The N-terminal cytomplasmic region of TRPM2 contains four homologous domains with unknown function and a calmodulin-/CaM-binding IQ-like motif, which is important for channel activation
- Its C-terminal cytomplasmic region contains the TRP box, a coiled-coil domain required for the assembly of TRPM2 channels, and an adenosine diphosphate ribose (ADPR) pyrophosphatase domain (Nudix-like domain or NUDT9 homology domain [NUDT9-H])
- ADPR binds to the NUDT9-H domain and, in the presence of Ca2+, gates channel opening
- TRPM2 activation also results in hydrolysis of ADPR into adenine monophosphate (AMP) and ribose-5-phosphate
- TRPM2 is a temperature-sensitive Ca2+-permeable ion channel expressed in various tissues, including brain, lungs, liver, spleen, heart, salivary gland, and pancreas
- TRPM2 is involved in redox response, cell proliferation, and insulin secretion by pancreatic β cells
- TRPM2 plays a pivotal role in the death of CA1 pyramidal cells and in the development of post-ischemic brain injury
- TRPM2 defect is associated with central nervous system disorders such as bipolar disorder type I, amyotrophic lateral sclerosis, Parkinson’s disease, and dementia.