MilliporeSigma™ SENP1, Mouse, Unlabeled, Clone: 8B6.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS1196MI-Each-of-1 | In Stock | ₹ 40,292.08 |
MABS1196MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,292.08
GST (18%): ₹ 7,252.574
Total Price: ₹ 47,544.654
Antigen
SENP1
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Mouse monoclonal IgG2bλ hybridoma culture supernatant with 0.05% Sodium Azide.
Gene Accession No.
Q9P0U3
Immunogen
GST-tagged recombinant fragment from the C-terminal half of human SENP1.
Quantity
100 μL
Research Discipline
Signaling
Gene ID (Entrez)
NP_001254523
Target Species
Human
Form
Culture Supernatant
Applications
Western Blot
Clone
8B6.1
Conjugate
Unconjugated
Gene
SENP1
Host Species
Mouse
Purification Method
Unpurified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Expected to react with both spliced isoforms of human SENP1 reported by UniProt (Q9P0U3).
Content And Storage
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype
IgG2b λ
Related Products
Description
- Sentrin-specific protease 1 (EC 3.4.22.68; UniProt Q9P0U3; also known as Sentrin/SUMO-specific protease SENP1) is encoded by the SENP1 gene (Gene ID 29843) in human
- SUMOylation, protein posttranslation modification by small ubiquitin-like modifier (SUMO), is a signaling event in many cellular processes
- As is the case with ubiquitination, SUMOylation is a reversible process
- SUMO E1 activating enzyme, E2 conjugating enzyme, and E3 ligase mediate SUMOylation of substrate proteins, while a family of SUMO-specific proteases (SENPs) are responsible for the deSUMOylation
- Seven SENPs are identified in human (SENP1-3 and SENP5-8)
- SENP1 processes full-length SUMO1, SUMO2 and SUMO3 to their mature forms and mediates their removal (deconjugation) from substrate proteins, including BHLHE40/DEC1, CCAR2, CLOCK, DBC1, HADC1, HIPK2, MTA1, p53, and SIRT1
- SENP1 is reported to be overexpressed and induced by IL-6 in multiple myeloma (MM) cells, and SENP1-knockdown triggers apoptosis and reduces viability, proliferation and colony forming ability of MM cells.