MABS1182
MilliporeSigma™ RagA/B, Mouse, Unlabeled, Clone: 1H7.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS1182-Each-of-1 | In Stock | ₹ 44,393.20 |
MABS1182 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,393.20
GST (18%): ₹ 7,990.776
Total Price: ₹ 52,383.976
Antigen
RagA/B
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse IgG2a in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
Q7L523
Immunogen
KLH-conjugated linear peptide corresponding to the C-terminal end sequence of human/mouse/rat RagA.
Quantity
100 μL
Research Discipline
Signaling
Gene ID (Entrez)
NP_006561
Target Species
Human
Form
Purified
Applications
Immunocytochemistry, Western Blot
Clone
1H7.1
Conjugate
Unconjugated
Gene
RRAGA
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 1H7.1 targets an epitope within the C-terminal end sequence highly conserved between RagA and RagB.
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG2a κ
Related Products
Description
- Ras-related GTP-binding protein A (UniProt Q7L523; also known as Adenovirus E3 14.7 kDa-interacting protein 1, FIP-1
- Rag A, RagA) is encoded by the RRAGA gene (Gene ID 10670) in human
- Mammalian cells express four Rag GTPases that mediate amino acid sufficiency-dependent mTORC1 activation to support cell growth and proliferation
- Rag GTPases assemble into heterodimers containing GTP-loaded RagA or RagB partnered with GDP-loaded RagC or RagD
- Promoted by signal from an upstream amino acid-responsive supercomplex, the active Rag heterodimer accumulates on the cytoplasmic surface of the lysosome, where it recruits mTORC1 and initiates its activation
- The pentameric Ragulator complex tethers Rag heterodimers to the lysosomal membrane and acts as RagA/B guanine nucleotide exchange factor (GEF), while the heterotrimeric GATOR1 complex and the heterodimeric FNIP-Folliculin complex function as RagA/B and RagC/D GTPase activating protein (GAP), respectively
- Both lysosomal amino acid sensors, such as the multisubunit vacuolar ATPase (v-ATPase) and lysosomal amino acid transporter(s), and cytoplasmic amino acid sensors, such as the leucyl-tRNA synthetase (LeuRS), are part of the upstream amino acid-responsive supercomplex.