MABS1304MI
MilliporeSigma™ anti-ATP Synthase subunit beta Clone: 11/21-7-A8,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS1304MI-Each-of-1 | In Stock | ₹ 42,114.80 |
MABS1304MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,114.80
GST (18%): ₹ 7,580.664
Total Price: ₹ 49,695.464
Antigen
ATP Synthase subunit β
Classification
Monoclonal
Conjugate
Unconjugated
Gene Accession No.
P06576
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Form
Purified
Applications
Dot Blot, ELISA, Immunocytochemistry, Western Blot
Clone
11/21-7-A8
Formulation
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
ATP5B, ATPMB, ATPSB
Immunogen
His-tagged recombinant protein corresponding to human ATP Synthase subunit β.
Quantity
100 μg
Research Discipline
Signaling
Gene ID (Entrez)
NP_001677
Content And Storage
2°C to 8°C for one year from date of shipment
Isotype
IgG1 κ
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Description
- Specifically detects ATP Synthase subunit β Clone: 11/21-7-A8 in Human, Mouse, Rat samples, and it is validated for Dot Blot, ELISA, Immunocytochemistry, Western Blotting ATP synthase subunit beta, mitochondrial (EC 3.6.3.14; UniProt P06576; also known as ATP synthase H+ transporting mitochondrial F1 complex beta polypeptide, beta-F1-ATPase, Epididymis secretory protein Li 271, Mitochondrial ATP synthase beta subunit, Mitochondrial ATP synthetase beta subunit) is encoded by the ATP5B (also known as ATPMB, ATPSB, HEL-S-271) gene (Gene ID 506) in human
- Mitochondrial ATP synthase produces ATP from ADP in the presence of a proton gradient generated by electron transport complexes
- This ATPase contains two structural domains, F1-containing extramembrane catalytic core, and F0-containing the membrane proton channel that are linked via a central stalk and a peripheral stalk
- Subunits alpha and beta form the catalytic code in F1
- Tumor development requires the selection of cancer cells with a repressed biogenesis and functional activity of mitochondria
- Both beta-F1-ATPase/GAPDH and beta-F1-ATPase/Hsp60 ratios are found to be significantly lower in tumors than the corresponding normal tissues
- Studies conducted in human colon cancer cell line HCT116 show the involvement of AMPK (AMP-activated protein kinase) and GCN2 (general control non-derepressible 2; eIF2α kinase) in the onset of colon cancer progression by repressing of beta-F1-ATPase synthesis and promoting the abnormal bioenergetics of mitochondria.