MABS1222MI
MilliporeSigma™ Mouse anti-MAN1B1, Clone: 1D6,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS1222MI-Each-of-1 | In Stock | ₹ 40,292.08 |
MABS1222MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,292.08
GST (18%): ₹ 7,252.574
Total Price: ₹ 47,544.654
Antigen
MAN1B1
Classification
Monoclonal
Formulation
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
MAN1B1
Immunogen
GST-tagged recombinant protein corresponding to human MAN1B1.
Quantity
200 μg
Research Discipline
Signaling
Gene ID (Entrez)
NP_057303
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
Isotype
IgG1 κ
Applications
Immunocytochemistry, Immunoprecipitation, Western Blot
Clone
1D6
Gene Accession No.
Q9UKM7
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human, Rat
Form
Purified
Related Products
Description
- Specifically detects MAN1B1 clone: 1D6 in Human, Rat samples, and it is validated for Immunocytochemistry, Immunoprecipitation, Western Blotting Endoplasmic reticulum (ER) mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113; UniProt Q9UKM7), also known as ER mannosyl-oligosaccharide 1,2-alpha-mannosidase, ER alpha-1,2-mannosidase, ERMan1, ERManI, ER mannosidase 1, Man9GlcNAc2-specific-processing alpha-mannosidase, Mannosidase alpha class 1B member 1) is encoded by the MAN1B1 gene in human
- Originally thought to function in a similar fashion as its yeast ortholog Mns1p, which removes a terminal mannose unit to initiate a glycan-based ER-associated degradation (ERAD) signal
- Mammalian MAN1B1 protein is actually localized in Golgi instead of ER
- MAN1B1 protein participates in a Golgi-based quality control network that captures misfolded protein substrate, which escape from ER, most likely via COPII vesicles, and recycles them back to the ER for ERAD
- Upon entering the Golgi, the initially escasped unfold proteins are retained by a cargo-capturing complex in which non-enzymatic regions of MAN1B1, including the decapeptide sequence (DPS) within the MAN1B1 luminal stem, play an integral role
- Facilitated by direct interactions with gamma-COP, MAN1B1 promotes the recruitment of unfold proteins into COPI vesicles, which then recycles the unfold proteins back to the ER via retrograde COPI vesicles without the need for trimming by MAN1B1 protein.