LXR alpha, Mouse anti-Mouse, Rat, Clone: 2B7, Millipore Sigma™
Manufacturer: MilliporeSigma
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS200025-Each-of-1 | In Stock | ₹ 16,643.00 |
MABS200025 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 16,643.00
GST (18%): ₹ 2,995.74
Total Price: ₹ 19,638.74
Antigen
LXR alpha
Classification
Monoclonal
Conjugate
Unconjugated
Formulation
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols
Nr1h3;Lxra
Immunogen
GST-tagged full length recombinant rat LXR-alpha protein.
Quantity
25 μg
Research Discipline
Signaling
Test Specificity
Clone 2B7 detects LXR-alpha in mouse and rat liver tissue.
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Isotype
IgG1
Applications
Immunoprecipitation, Western Blot
Clone
2B7
Dilution
Immunoprecipitation Analysis: A representative lot detected LXR alpha in Immunoprecipitation applications (Tian, J., et. al. (2016). Proc Natl Acad Sci USA. 113(29):8182-7).Western Blotting Analysis: A representative lot detected LXR alpha in Western Blotting applications (Tian, J., et. al. (2016). Proc Natl Acad Sci USA. 113(29):8182-7).
Gene Alias
Oxysterols receptor LXR-alpha;Liver X receptor alpha;Nuclear receptor subfamily 1 group H member 3;RLD-1
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Mouse, Rat
Form
Purified
Related Products
Description
- Anti-LXR alpha, clone 2B7, Cat
- No
- MABS2000, is a mouse monocloanl antibody that detects Oxysterols receptor LXR-alpha and has been tested for use in Immunoprecipitation and Western Blotting
- Oxysterols receptor LXR-alpha (UniProt: Q62685; also known as Liver X receptor alpha, Nuclear receptor subfamily 1 group H member 3, RLD-1) is encoded by the Nr1h3 (also known as Lxra) gene in rat
- Liver X receptors (LXRs) are members of the nuclear receptor superfamily that have been implicated in lipid homeostasis and glucose metabolism
- Oxysterols, oxidized derivatives of cholesterol, are ligands for LXRs
- LXRs act as cholesterol sensors; when cellular oxysterols accumulate as a result of increasing concentrations of cholesterol, LXR induces the transcription of genes that protect cells from cholesterol overload
- LXRs bind to consensus elements (LXR response elements, LXREs) as heterodimers with isoforms of the retinoid X receptor (RXR)
- LXR-alpha is an important regulator of cholesterol and bile acid metabolism
- It interacts with RXR and shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES
- In adults it is expressed in spleen, pituitary, lung, liver, and fat and a weaker expression is observed in several other tissues
- LXR-alpha contains a transactivation domain (AF-1; aa 1-94) that is required for ligand-independent transactivation function; another transactivation domain (AF-2; aa 203-445) that is required for ligand-dependent transactivation function; and a ligand binding domain (aa 213-432)
- (Ref.: Zhao, C., and Dahlman-Wright, K
- (2010)
- J
- Endocrinol
- 204, 233-240).