MABS430MI
MilliporeSigma™ Mouse anti-Mcpip1, Clone: 2H8.2,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS430MI-Each-of-1 | In Stock | ₹ 38,958.86 |
MABS430MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,958.86
GST (18%): ₹ 7,012.595
Total Price: ₹ 45,971.455
Antigen
Mcpip1
Classification
Monoclonal
Formulation
Purified mouse monoclonal IgG2aκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
ZC3H12A; MCPIP; MCPIP1
Immunogen
GST-tagged recombinant protein corresponding to human Mcpip1.
Quantity
100 μg
Research Discipline
Signaling
Gene ID (Entrez)
NP_079355
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
Isotype
IgG2a κ
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin)
Clone
2H8.2
Gene Accession No.
Q5D1E8
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Purified
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Description
- Specifically detects Mcpip1 clone: 2H8.2 in Human samples, and it is validated for Immunocytochemistry, Immunohistochemistry (Paraffin) MCP-induced protein 1 (also known as ribonuclease ZC3H12A, Zinc finger CCCH domain-containing protein 12A) is encoded by the ZC3H12A gene in human (also known as dJ423B22.1, MCPIP, MCPIP1)
- It belongs to the 4-member CCCH-zinc finger protein family (MCPIP1/2/3/4) that act as negative regulators in macrophage activation (PMID 18178554)
- MCPIP1 in particular is involved in immune response downregulation upon LPS treatment by targeting IL-6 and IL-12b with its RNase activity (PMID 22561375)
- MCPIP1 expresssion by MCP-1 treatment is reported to promote angiogenesis in human umbilical vein endothelial cell (HUVEC) cultures, while causing apoptotic cell death in cardiac myocytes (PMID 18364357 & 16574901).