CD46 Antibody (122.2), PE/Atto594, Novus Biologicals™
Manufacturer: Novus Biologicals
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | N233159P594-Each-of-1 | In Stock | ₹ 63,991.00 |
N233159P594 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 63,991.00
GST (18%): ₹ 11,518.38
Total Price: ₹ 75,509.38
Antigen
CD46
Classification
Monoclonal
Conjugate
PE/ATTO 594
Formulation
PBS with 0.05% Sodium Azide
Gene Symbols
CD46
Immunogen
Recombinant human CD46 protein (Uniprot: P15529)
Quantity
0.1 mL
Primary or Secondary
Primary
Test Specificity
CD46 acts as a cofactor for complement factor I, a serine protease, which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells, which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
Content And Storage
Store at 4°C in the dark. Do not freeze.
Applications
Flow Cytometry
Clone
122.2
Dilution
Flow Cytometry
Gene Alias
AHUS2, CD46 antigen, CD46 molecule, complement regulatory protein, membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen), MIC10, TLXcomplement regulatory protein, trophoblast leucocyte common antigen, Trophoblast leukocyte common antigen, trophoblast-lymphocyte cross-reactive antigen
Host Species
Mouse
Purification Method
Protein A or G purified
Research Discipline
Cancer, Cell Biology, Cellular Markers, Immunology
Gene ID (Entrez)
4179.0
Target Species
Human
Isotype
IgG1 κ
Related Products
Description
- CD46 Monoclonal specifically detects CD46 in Human samples
- It is validated for Flow Cytometry.