CD8 Antibody (C8/468), Allophycocyanin/Cy7, Novus Biologicals™

CD8

Monoclonal

APC-Cyanine7

PBS with 0.05% Sodium Azide

CD8A

Human CD8 recombinant protein (Uniprot: P01732 )

0.1 mL

Primary

CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.

Store at 4°C in the dark. Do not freeze.

Flow Cytometry

C8/468

Flow Cytometry

CD8, CD8a molecule, LEU2, p32

Mouse

Protein A or G purified

Adaptive Immunity, Cytokine Research, Immunology, Immunophenotyping, Innate Immunity, Phospho Specific, Signal Transduction, Stem Cell Markers

925.0

Human

IgG1 κ