Integrin beta 4/CD104 Antibody (UM-A9), PE/Cy7, Novus Biologicals™

Integrin beta 4/CD104

Monoclonal

PE-Cyanine7

PBS with 0.05% Sodium Azide

ITGB4

Human squamous cell carcinoma (UM-SCC1)

0.1 mL

Primary

Recognizes a protein of 205kDa, which is identified as integrin beta-4 (ITGB4). Its epitope is localized in the extracellular domain of ITGB4 protein. Integrins are heterodimers comprised of alpha and beta subunits, that are non-covalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta-4 subunit, a receptor for the laminins. This subunit tends to associate with alpha-6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Store at 4°C in the dark. Do not freeze.

Flow Cytometry

UM-A9

Flow Cytometry

CD104, CD104 antigen, GP150, integrin beta-4, integrin beta-4 subunit, integrin, beta 4

Mouse

Protein A or G purified

Adaptive Immunity, Immunology, Phospho Specific, Signal Transduction

3691.0

Human

IgG2a κ