CD81 Antibody (1.3.3.22), Allophycocyanin/Cy7, Novus Biologicals™

CD81

Monoclonal

APC-Cyanine7

PBS with 0.05% Sodium Azide

CD81

Recombinant full-length human CD81 protein (Uniprot: P60033)

0.1 mL

Primary

Recognizes a protein of 26kDa, identified as CD81 (Workshop VI; Code CD81.1)). CD81 has a very broad cellular distribution, being expressed on T- and B-lymphocytes, NK cells, thymocytes, eosinophils, fibroblasts, epithelial and endothelial cells. Neutrophils, erythrocytes and platelets are negative, while monocytes are variably positive. CD81 is a member of a family of tetraspans transmembrane proteins, including CD9, CD37, CD53, CD63, and CD82. It associates with CD19, CD21, Leu 13, and integrins on cell membrane and is involved in signal transduction in B lymphocyte development and cell adhesion. CD81 also acts as a receptor for the envelope protein E2 of chronic hepatitis C virus. Antibodies to CD81 have anti-proliferative effects on different lymphoid cell lines, particularly those derived from large cell lymphomas.

Store at 4°C in the dark. Do not freeze.

Flow Cytometry, Immunoassay

1.3.3.22

Flow Cytometry, Flow (Cell Surface), Knockout Validated

CD81 antigen, CD81 antigen (target of antiproliferative 1), CD81 molecule, CVID6, TAPA1, TAPA-1, Target of the antiproliferative 1, Tetraspanin-28, Tspan-28, tspan-28,26 kDa cell surface protein TAPA-1, TSPAN28S5.7

Mouse

Protein A or G purified

Adaptive Immunity, Cell Cycle and Replication, Immunology

975.0

Human, Mouse, Rat

IgG1 κ