PTH Antibody (PTH/2295R), Janelia Fluor™ 646 - N-terminal, Novus Biologicals™

PTH

Monoclonal

Janelia Fluor 646

50mM Sodium Borate with 0.05% Sodium Azide

PTH

A recombinant fragment around aa 32-115 of human mature-PTH-polypeptide (exact sequence is proprietary) (Uniprot: P01270)

0.1 mL

Apoptosis, Biologically Active Proteins, Cancer

Epitope of this monoclonal antibody maps in between aa 1-34. PTH is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Store at 4°C in the dark.

Immunohistochemistry, Immunohistochemistry (Paraffin)

PTH/2295R

Immunohistochemistry, Immunohistochemistry-Paraffin

Parathormone, Parathyrin, parathyroid hormone, parathyroid hormone 1, PTH1

Rabbit

Protein A or G purified

RUO

Primary

Human

IgG