RB1 Antibody (172C1094), Alexa Fluor™ 405 - (cleaved), Novus Biologicals™

cleaved Retinoblastoma 1

Monoclonal

Alexa Fluor 405

50mM Sodium Borate with 0.05% Sodium Azide

RB1

A synthetic peptide corresponding to a region of the caspase-3-induced cleavage site of human Rb was used as immunogen.

0.1 mL

Cancer, Cell Cycle and Replication, Transcription Factors and Regulators, Tumor Suppressors

5925

Human, Mouse

Purified

Western Blot, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen), KnockDown

172C1094

Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Knockdown Validated

OSRC, osteosarcoma, p105-Rb, pp110, pRb, Rb, retinoblastoma 1, retinoblastoma suspectibility protein, retinoblastoma-associated protein

Mouse

Protein G purified

RUO

Primary

The antibody recognizes cleaved Rb (DRb-p70). The antibody does not recognize full-length Rb. In camptothecin treated HL60, an ∼68 kDa band is observed. DRb-p70 exists in vivo as an N-terminally truncated form of Rb (Liu et al.). DRb-p70 is thought to be the product of alternative translation and is expressed in primary myeloid cells in fetal liver, bone marrow and spleen. DRb-p70 is also specifically expressed in tumor-associated macrophages (TAMs). TAMs are an important targets of cancer therapy. DRb-p70 is a marker of TAMs, and maybe useful for identifying tumors with macrophage infiltration (Liu et al, 2005).

Store at 4C in the dark.

IgG1