GAD1/GAD67 Antibody (GAD1/2563), DyLight 594, Novus Biologicals™

GAD1/GAD67

Monoclonal

DyLight 594

50mM Sodium Borate with 0.05% Sodium Azide

GAD1

Recombinant human GAD1/GAD67 protein fragment (around aa 72-135) (exact sequence is proprietary) (Uniprot: Q99259)

0.1 mL

Diabetes Research

This monoclonal antibody recognizes a protein of 67kDa, which is identified as glutamic acid decarboxylase 1 (GDA1). There are two forms of glutamic acid decarboxylases (GADs) that are found in the brain: GAD65 (also known as GAD2) and GAD67 (also known as GAD1. GAD65 and GAD67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate-limiting step in the production of GABA (-aminobutyric acid) from L-glutamic acid. Although both GADs are found in the brain, GAD65 localizes to synaptic vesicle membranes in nerve terminals, while GAD67 is distributed throughout the cell. GAD67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD65 will transiently activate to assist in GABA production. The loss of GAD65 is detrimental and can impair GABA neurotransmission, however the loss of GAD67 is lethal.

Store at 4°C in the dark.

Western Blot, Flow Cytometry, ELISA

GAD1/2563

Western Blot, Flow Cytometry, ELISA

67kD), EC 4.1.1, FLJ45882, GAD25, glutamate decarboxylase 1 (brain, 67kDa), Glutamate decarboxylase 67 kDa isoform

Mouse

Protein A or G purified

RUO

Primary

Human

IgG2b κ