TTF-1/ NKX2-1 Antibody (8G7G3/1 + NX2.1/690), PerCP, Novus Biologicals™

TTF-1 / NKX2-1

Monoclonal

PerCP

PBS with 0.05% Sodium Azide

NKX2-1

Rat full length TTF-1/ NKX2-1 recombinant protein (8G7G3/1); Recombinant TTF-1/ NKX2-1 protein (NX2.1/690) (Uniprot: P43699)

0.1 mL

Primary

Recognizes a protein of 40kDa, identified as Thyroid transcription factor-1 (TTF-1). TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates.Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies.

Store at 4C in the dark.

IgG1 κ

Flow Cytometry

8G7G3/1 + NX2.1/690

Flow Cytometry

benign chorea, Homeobox protein NK-2 homolog A, homeobox protein Nkx-2.1, NK2 homeobox 1, NK-2 homolog A, NKX2ANKX2.1, Thyroid nuclear factor 1, Thyroid transcription factor 1BHC, TITF1TEBP, TTF1, TTF1BCH, TTF-1NK-2

Mouse

Protein A or G purified

Membrane Trafficking and Chaperones, Tumor Biomarkers

7080

Human, Mouse, Rat

Purified