CD46 Antibody (122.2), Novus Biologicals™

CD46

Monoclonal

0.2mg/mL

Flow Cytometry 0.5-1ug/million cells in 0.1ml, SDS-Page, Immunofluorescence 0.5-1ug/ml

NP_002380

CD46

A recombinant protein fragment specific for human CD46 was used as the immunogen.

0.2 mg

Cancer, Cell Biology, Cellular Markers, Immunology

4179

Human

Purified

Flow Cytometry, SDS-Page, Immunofluorescence

122.2

Unconjugated

PBS with 0.05% BSA. with 0.05% Sodium Azide

AHUS2, CD46 antigen, CD46 molecule, complement regulatory protein, membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen), MIC10, TLXcomplement regulatory protein, trophoblast leucocyte common antigen, Trophoblast leukocyte common antigen, trophoblast-lymphocyte cross-reactive antigen

Mouse

Protein G purified

RUO

Primary

CD46 acts as a cofactor for complement factor I, a serine protease, which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells, which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

Store at 4C.

IgG1 κ