Plasma Cell Antibody (LIV3G11 (7B18)), Novus Biologicals™

Plasma Cell

Monoclonal

0.2 mg/ml

Immunohistochemistry-Paraffin 0.5-1ug/ml

Mouse

Protein A or G purified

RUO

Primary

Human, Rat (Negative)

Purified

Immunohistochemistry (Paraffin)

LIV3G11 (7B18)

Unconjugated

Plasma

Pancreatic cancer related serum mucin was used as the immunogen for the Plasma Cell antibody.

0.1 mg

Immunology

It recognizes an intra-cytoplasmic antigen, which shows a very high degree of specificity for plasma cells. This antigen is present in normal as well as neoplastic plasma cells. Plasma cells, which are large lymphocytes derived from an antigen-specific B cell, secrete antibodies and are responsible for humoral immunity. Plasma cells differentiate from B cells upon stimulation by CD4+ lymphocytes. The B cell acts as an antigen-presenting cell (APC), consuming an offending pathogen, which is taken up by the B cell by phagocytosis and broken down within proteosomes. Plasma cells contain basophilic cytoplasm; their nucleus contains heterochromatin organized in a characteristic cartwheel arrangement. This monoclonal antibody superbly recognizes normal and neoplastic plasma cells in routine formalin-fixed, paraffin-embedded tissue sections. It is of potential value in identifying myeloma or plasmacytoma in bone marrow or other tissues. It also helps differentiate lympho-plasmacytoid lymphoma

Store at 4C.

IgG2a κ