Pax6 Antibody (PAX6/498), Alexa Fluor™ 405, Novus Biologicals™

Pax6

Monoclonal

Alexa Fluor 405

keratitis), MGC17209, Oculorhombin, paired box 6, paired box protein Pax-6

Mouse

47 kDa

0.1 mL

Cellular Markers, Diabetes Research, Neuronal Stem Cell Markers, Neuroscience, Sensory Systems, Stem Cell Markers, Stem Cells, Transcription Factors and Regulators, Vision

5080

Human, Mouse, Rat, Chicken

Purified

Western Blot, Flow Cytometry, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen)

PAX6/498

Western Blot, Flow Cytometry, ELISA, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Frozen

PAX6

Recombinant fragment (N-terminus; aa 1-300) of human PAX6 protein

Protein A or G purified

RUO

Primary

Pax genes contain paired domains with strong homology to genes in Drosophila, which are involved in programming early development. Lesions in the Pax-6 gene account for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. Pax-6 is involved in other anterior segment malformations besides aniridia, such as Peters anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The Pax-6 gene encodes a transcriptional regulator that recognizes target genes through its paired-type DNA-binding domain. The paired domain is composed of two distinct DNA-binding subdomains, the amino-terminal subdomain and the carboxy-terminal subdomain, which bind respective consensus DNA sequences. The human Pax-6 gene produces two alternatively spliced isoforms that have the distinct structure of the paired domain.

Store at 4C in the dark.

IgG1 κ