Perforin Antibody (PRF1/2468) - Azide and BSA Free, Novus Biologicals™

Perforin

Monoclonal

0.2 mg/ml

Immunohistochemistry-Paraffin 1-2 ug/ml

P14222

PRF1

Recombinant human Perforin protein fragment (around aa 413-552) (exact sequence is proprietary) (Uniprot: P14222)

Protein A or G purified

Adaptive Immunity, Apoptosis, Immunology, Innate Immunity

5551.0

Human

Purified

Immunohistochemistry (Paraffin)

PRF1/2468

Unconjugated

10 mM PBS with No Preservative

Cytolysin, FLH2, HPLH2, HPLH2lymphocyte pore forming protein, Lymphocyte pore-forming protein, MGC65093, P1PFN1, perforin 1 (pore forming protein), perforin-1, PFPcytolysin

Mouse

75 kDa

100 μg

Primary

Perforin is a pore-forming protein that leads to osmotic lysis of the target cells and subsequently enables granzymes to enter the target cells and activate apoptosis. Perforin has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. It is one of the main cytolytic proteins of cytolytic granules, and is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. The expression of perforin is reportedly upregulated in activated CD8+ T-cells, natural killer cells and some CD4+ T-cells.

Store at 4°C.

IgG2b κ