Bcl-2 Antibody (BCL2/2210R) - Azide and BSA Free, Novus Biologicals™

Bcl-2

Monoclonal

0.2 mg/ml

Western Blot 0.5 - 1 μg/mL, Immunohistochemistry, Immunocytochemistry/Immunofluorescence 1 - 2 μg/mL, Immunohistochemistry-Paraffin 0.5 - 1 μg/mL, Protein Array

P10415, P10415

BCL2

Recombinant full-length human bcl-2 protein (Uniprot: P10415)

100 μg

Primary

This antibody recognizes a protein of 25-26kDa, identified as the Bcl-2 lpha oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of Bcl-2 lpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of Bcl-2 lpha protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express Bcl-2 protein and the small number in which the neoplastic cells are Bcl-2 negative.

Store at 4°C.

IgG

Western Blot, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Peptide Array

BCL2/2210R

Unconjugated

10 mM PBS with No Preservative

apoptosis regulator Bcl-2, B-cell CLL/lymphoma 2, Bcl-2

Rabbit

Protein A or G purified

Apoptosis, Autophagy, Biologically Active Proteins, Cancer, Cellular Markers, Mitochondrial Mediated Pathway, Mitophagy, Oncogenes, Tumor Suppressors

596.0

Human

Purified