Cyclophilin A Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA1025-Each-of-1 | In Stock | ₹ 48,193.50 |
PA1025 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,193.50
GST (18%): ₹ 8,674.83
Total Price: ₹ 56,868.33
Antigen
Cyclophilin A
Classification
Polyclonal
Formulation
PBS with 0.05% sodium azide
Gene Accession No.
P14851, P17742, P62937
Gene Symbols
Ppia
Immunogen
Purified recombinant human CyPA.
Quantity
400 μL
Primary or Secondary
Primary
Target Species
Hamster, Human, Mouse
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Western Blot
Conjugate
Unconjugated
Gene
Ppia
Gene Alias
2700098C05; Cphn; CYCA; cyclophilin; Cyclophilin A; Cyclosporin A-binding protein; CyP A; CyP-18; CYPA; CyP-A; CYPH; EC 5.2.1.8; epididymis secretory sperm binding protein Li 69p; HEL-S-69p; HGNC:9253; I79_011869; MGC117158; MGC12404; MGC23397; p1B15; p31; Peptidyl-prolyl cis-trans isomerase A; Peptidyl-prolyl cis-trans isomerase A, N-terminally processed; peptidylprolyl isomerase A; peptidylprolyl isomerase A (cyclophilin A); PPIA; PPIase; PPIase A; rotamase; rotamase A; SP18; T cell cyclophilin
Host Species
Rabbit
Purification Method
Ammonium sulfate precipitation
Regulatory Status
RUO
Gene ID (Entrez)
100769490, 268373, 5478
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- PA1-025 detects recombinant human cyclophilin A (CyPA), but does not detect endogenous levels of CyPA
- PA1-025 also detects the CyPA protein from CHO cells
- PA1-025 has been successfully used in Western blot and ICC/IF procedures
- By Western blot, this antibody detects a prominent ∽18 kDa protein representing recombinant human CyPA
- The PA1-025 immunogen is recombinant human CyPA expressed in E
- coli
- Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506
- Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs) and those that bind cyclosporin A are called cyclophilins (CyP)
- Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation, providing a possible mechanism of immunosuppression by CsA and FK506
- Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds
- As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins
- Within the cyclophilin family, there are several different proteins which show a high degree of homology including CyPA, CyPB and CyPC
- CyPA, also termed CyP-18, is the most abundant and ubiquitous cyclophilin found in all vertebrate tissues and is present in T-cells.