WWTR1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA14218-Each-of-1 | In Stock | ₹ 46,591.50 |
PA14218 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,591.50
GST (18%): ₹ 8,386.47
Total Price: ₹ 54,977.97
Antigen
WWTR1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
WWTR1
Gene Alias
2310058J06Rik; 2610021I22Rik; C78399; DKFZp586I1419; FLJ27004; FLJ45718; Tafazzin; TAZ; transcriptional coactivator with PDZ binding motif; transcriptional co-activator with PDZ-binding motif; transcriptional coactivator with PDZ-binding motif; transcriptional co-activator with PDZ-binding motif (TA)Z; transcriptional co-activator with PDZ-binding motif (TAZ); WW domain containing transcription regulator 1; WW domain-containing transcription regulator protein 1; Wwtr1
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
25937, 295062, 97064
Content And Storage
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form
Liquid
Applications
Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.02% sodium azide
Gene Accession No.
Q9EPK5, Q9GZV5
Gene Symbols
WWTR1
Immunogen
Synthetic peptide corresponding to residues V(386) E S A L N K S E P FL T W L(400) of the PDZ-binding domain of human TAZ.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- PA1-4218 detects the TAZ protein in human, mouse, and rat samples
- PA1-4218 has been successfully used in Western blot procedures
- By Western blot this antibody detects a ∽49 kDa protein representing TAZ in MDCK cells
- The PA1-4218 immunogen is a synthetic peptide corresponding to residues V(386) E S A L N K S E P FL T W L(400) of the 49kDa human TAZ protein
- WW domain-containing transcription regulator protein 1 (WWTR1) is a transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor supression by restricting proliferation and promoting apoptosis
- The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1
- In turn, MOB1 phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ
- WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation
- WWTR1 regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex
- WWTR1 also regulates embryonic stem-cell self-renewal and promotes cell proliferation and epithelial-mesenchymal transition.