PA14358
Humanin Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA14358-Each-of-1 | In Stock | ₹ 48,905.50 |
PA14358 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,905.50
GST (18%): ₹ 8,802.99
Total Price: ₹ 57,708.49
Antigen
Humanin
Classification
Polyclonal
Conjugate
Unconjugated
Gene
MT-RNR2
Gene Alias
BCL2L4; HN1; Humanin-like 1; humanin-like protein 1; mitochondrially encoded 16S RNA; MTRNR2; MT-RNR2; MTRNR2L1; MT-RNR2-like 1; MTRNR2-like 1; MT-RNR2-like protein 1; RNR2
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
4550
Content And Storage
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form
Liquid
Applications
Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.02% sodium azide
Gene Accession No.
Q8IVG9
Gene Symbols
MT-RNR2
Immunogen
Synthetic peptide corresponding to residues L(9) L L L T S E I D L P V K R R A(24) of human Humanin.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- PA1-4358 detects Humanin from human samples
- PA1-4358 has been successfully used in Western blot procedures
- The PA1-4358 immunogen is a synthetic peptide corresponding to residues L(9) L L L T S E I D L P V K R R A(24) of human Humanin
- Humanin is a novel 24 A
- A polypeptide identified in Alzheimer's disease-affected brain
- It is 99% homologous to mitochondrial 16s ribosomal RNA and functions as a novel neuroprotective and cytoprotective factor
- It specifically inhibits neuronal cell death induced by beta-amyloids and Alzheimer's disease causing FAD genes by competitively inhibiting access of FPRL1 receptor to beta-amyloids
- It acts as an anti-apoptotic factor by binding to Bcl-2/Bax family of pro-apoptotic factors including Bax, Bak, Bid and BimEL and inhibits their pro-apoptotic activity
- It activates JAK/STAT signaling pathway and is regulated by TRIM11
- It interacts with IGFBP-3 and specifically blocks IGFBP-3 induced cell death in glioblastoma cells
- Humanin is also expressed in colon and testis.