RELM alpha Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA14257-Each-of-1 | In Stock | ₹ 46,146.50 |
PA14257 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,146.50
GST (18%): ₹ 8,306.37
Total Price: ₹ 54,452.87
Antigen
RELM alpha
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Retnla
Gene Alias
1810019L16Rik; cysteine-rich secreted protein A12-gamma; Cysteine-rich secreted protein FIZZ1; Fizz1; Fizz-1; FIZZ2; found in inflammatory zone 1; Himf; HXCP2; Hypoxia-induced mitogenic factor; parasite-induced macrophage novel gene 1 protein; Pmng1; RELMa; RELMalpha; RELM-alpha; RELMb; RELMbeta; RELM-beta; resistin like alpha; resistin-like alpha; Retnla; Xcp2
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
57262
Content And Storage
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form
Liquid
Applications
Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.02% sodium azide
Gene Accession No.
Q9EP95
Gene Symbols
Retnla
Immunogen
Synthetic peptide corresponding to residues V(31) E N K V K E L L A N P A N(44).
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- PA1-4257 detects the RELM alpha protein in mouse and human samples
- PA1-4257 has been successfully used in Western blot procedures
- By Western blot this antibody detects a ∽15 kDa protein corresponding to secreted mouse RELM alpha from the media of transfected 293T cells
- The PA1-4257 immunizing peptide corresponds to amino acid residues 31-44 of the mouse RELM alpha protein
- RELM alpha, also known as Resistin-like alpha or FIZZ1, is a small cytokine (88 aminoacids, MW 9.4 kDa) produced mostly by macrophages
- Its highest constitutive expression has been observed in small peritoneal macrophages, alveolar macrophages and adipose tissue macrophages
- It is strongly induced by IL-4 and IL-13
- Together with Arginase 1 and Ym-1, RELM alpha is considered one of the hallmarks of the M2 polarization of mouse macrophages, however, macrophages polarized with IL-10 (M2c) express neither RELM alpha nor Arginase 1
- Also, the expression patterns of RELM alpha and Arginase 1 in untreated tissue macrophages significantly differ
- Elevated levels of RELM alpha may indicate parasitic infection
- Humans do not have RELM alpha gene but human Resistin resembles mouse RELM alpha in respect to sequence, tissue distribution and function
- Other members of RELM family in mouse: RELM beta, RELM gamma and Resistin display different tissue distribution and functional properties
- RELM alpha plays an important role in parasite infection, mucosal inflammation and allergy.