CREB Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA1850-Each-of-1 | In Stock | ₹ 48,683.00 |
PA1850 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,683.00
GST (18%): ₹ 8,762.94
Total Price: ₹ 57,445.94
Antigen
CREB
Classification
Polyclonal
Conjugate
Unconjugated
Gene
CREB1
Gene Alias
2310001E10Rik; 3526402H21Rik; active transcription factor CREB; AV083133; cAMP response element binding protein 1; cAMP responsive element binding protein 1; cAMP-response element-binding protein-1; cAMP-responsive element-binding protein 1; CREB; CREB1; Creb-1; cyclic adenosine 3',5'-monophosphate response element-binding protein CREB; cyclic AMP-responsive element-binding protein 1; htCREB; MGC9284; OTTHUMP00000206661; OTTHUMP00000206662; OTTHUMP00000206667; transactivator protein; Y protein
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
12912, 1385, 81646
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
ChIP Assay, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 1mg/mL BSA and 0.05% sodium azide
Gene Accession No.
P15337, P16220, Q01147
Gene Symbols
CREB1
Immunogen
Synthetic peptide corresponding to residues K(123) R R E I L S R R P S Y R K(136) of human CREB.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- PA1-850 detects both the phosphorylated and non-phosphorylated forms of cyclic-AMP response element binding protein (CREB) from rat, mouse, and human samples
- PA1-850 has been successfully used in ChIP, Western blot, ICC/IF and IHC-P procedures
- By Western blot, this antibody detects an ∽43 kDa protein representing CREB from GH4 cell extract
- The PA1-850 immunogen is a synthetic peptide corresponding to residues K(123) R R E I L S R R P S Y R K(136) of human CREB
- This sequence is completely conserved between human, bovine, canine, mouse, pig, sheep, and rat CREB protein
- The PA1-850 immunizing peptide (Cat
- # PEP-142) is available for use in neutralization and control experiments
- CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors
- Activation of CREB is dependent upon the phosphorylation of serine 133
- Phosphorylation of CREB occurs via p44/42 MAP kinase and p90RSK, and via p38 MAP kinase and MSK1
- Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor
- CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133
- CREB is involved in different cellular processes including the synchronization of circadian rhythmicity, differentiation of adipose cells, and learning and memory
- In humans, the gene is located on the q arm of chromosome 2
- Diseases associated with CREB dysfunction include Alzheimer’s Disease, histiocytoma and soft tissue melanoma.