PMCA2 ATPase Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA1915-Each-of-1 | In Stock | ₹ 49,795.50 |
PA1915 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,795.50
GST (18%): ₹ 8,963.19
Total Price: ₹ 58,758.69
Antigen
PMCA2 ATPase
Classification
Polyclonal
Conjugate
Unconjugated
Gene
ATP2B2
Gene Alias
Atp2b2; ATPase isoform 2 Na+K+ transporting beta polypeptide 2; ATPase isoform 2, Na+K+ transporting, beta polypeptide 2; ATPase plasma membrane Ca2+ transporting 2; ATPase, Ca++ transporting, plasma membrane 2; D6Abb2e; deaf waddler; dfw; Gena300; jog; plasma membrane Ca(2+)-ATPase; plasma membrane Ca++-ATPase; plasma membrane Ca2+ pump 2; plasma membrane calcium ATPase; Plasma membrane calcium ATPase isoform 2; plasma membrane calcium pump; Plasma membrane calcium pump isoform 2; Plasma membrane calcium-transporting ATPase 2; PMCA2; PMCA2a; PMCA2i; Tmy; wms; wri; wriggle
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
100625418, 24215, 491
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
ELISA, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 1mg/mL BSA and 0.05% sodium azide
Gene Accession No.
P11506, Q01814
Gene Symbols
ATP2B2
Immunogen
Synthetic Peptide: T(5) N S D F Y S K N Q R N E S S(19)
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Porcine, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- PA1-915 detects calcium pump of the plasma membrane 2 (PMCA2 ATPase) from human and rat and porcine tissues and cells
- PA1-915 has been successfully used in Western blot procedures
- By Western blot, this antibody detects an ∽127 kDa protein and an ∽133 kDa protein representing PMCA2a and PMCA2b ATPase, respectively, from rat brain microsomal fractions
- PA1-915 immunizing peptide corresponds to amino acid residues 5-19 from human PMCA2 ATPase protein
- This sequence is completely conserved between human and rat PMCA2 ATPase
- The calcium pump of the plasma membrane, termed PMCA ATPase, pumps calcium from the cytosol to the extracellular space
- This membrane-bound enzyme is related to a number of other ATPases including the SERCA ATPase and the sodium/K+ pump
- There are four different genes encoding PMCA ATPase and studies have revealed 20 isoforms of the pump generated by alternate splicing of the primary gene products
- mRNA distribution studies show that gene products 1 and 4 are transcribed in most tissues, however, products 2 and 3 are more tissue specific
- Transcription of the splicing variants has also been found to be tissue specific
- In the pancreas, where insulin secretion is calcium dependent, the beta cells only express the 4b isoform, however the alpha and gamma cells express both 4a and 4b isoforms
- Studies have also shown that different splice variants have different affinities for calcium and calmodulin.