LAMP2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA1655-Each-of-1 | In Stock | ₹ 51,575.50 |
PA1655 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 51,575.50
GST (18%): ₹ 9,283.59
Total Price: ₹ 60,859.09
Antigen
LAMP2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
LAMP2
Gene Alias
CD107 antigen-like family member B; CD107b; EGK_20887; Igp96; Lamp II; LAMP2; LAMP-2; LAMP-2 Isoform 2A; LAMP-2 Variant A; Lamp-2a; Lamp-2b; Lamp-2c; LAMPB; LGP110; LGP-110; LGP-96; LGP-B; lysosomal associated membrane protein 2; lysosomal membrane glycoprotein 2; lysosomal membrane glycoprotein type B; lysosomal-associated membrane protein 2; lysosome-associated membrane glycoprotein 2; lysosome-associated membrane protein 2; Mac3; RP23-193O17.2
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
16784, 24944, 3920
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 1mg/mL BSA and 0.05% sodium azide
Gene Accession No.
P13473, P17046, P17047
Gene Symbols
LAMP2
Immunogen
Synthetic Peptide: C G(400) L K R H H T G Y E Q F(411)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- PA1-655 detects lysosome-associated membrane protein-2 (LAMP2) from rat, mouse and human tissues
- PA1-655 has been successfully used in Western blot, immunofluorescence, and immunohistochemistry
- By Western blot, this antibody detects glycosylated and non-glycosylated LAMP-2, depending on the lysis buffer used
- PA1-655 immunizing peptide corresponds to amino acid residues 400-411 from rat LAMP2
- This sequence is completely conserved between rat, mouse, and guinea pig LAMP2
- PA1-655 immunizing peptide (Cat
- # PEP-039) is available for use in neutralization and control experiments
- LAMP2 (Lysosome-associated membrane glycoprotein 2, CD107b) is a member of a family of membrane glycoproteins
- LAMP2 provides selectins with carbohydrate ligands, and may play a role in tumor cell metastasis, and have a function in the protection, maintenance, and adhesion of the lysosome
- Prior to posttranslational modification, LAMP2 is approximately 46 kDa polypeptide
- Mature, functional LAMP2 is extensively glycosylated with a variety of different N-linked and O-linked oligosaccharides with a total molecular weight of about 100-130 kDa
- LAMP 2 has a structure comprised of a large amino-terminal intra-lysosomal domain, a hydrophobic trans-membrane domain, and a short carboxyl-terminal cytoplasmic tail
- LAMP2 is used to monitor a very selective form of autophagy called chaperone-mediated autophagy
- LAMP 2 has a structure comprised of a large amino-terminal intra-lysosomal domain, a hydrophobic trans-membrane domain, and a short carboxyl-terminal cytoplasmic tail
- The LAMP protein has 3 variant forms: LAMP-2A, -2B, and 2C
- LAMP2, together with CD107a/LAMP-1, is a major constituent of lysosomal membrane
- The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes, and LAMP2 is an important regulator in successful phagosomal maturation
- LAMP2 deficiency causes an accumulation of autophagosomes in many tissues leading to cardiomyopathy and myopathy (Danon’s disease).