Phospho-p23 (Ser113) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA540250-Each-of-1 | In Stock | ₹ 46,502.50 |
PA540250 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
Phospho-p23 (Ser113)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Ptges3
Gene Alias
5730442A20Rik; Co chaperone p23; cPGES; cytosolic prostaglandin E synthase; cytosolic prostaglandin E2 synthase; Hsp90 co chaperone; Hsp90 co-chaperone; LOC100351480; P23; p23 cochaperone; progesterone receptor; progesterone receptor complex p23; Prostaglandin E synthase 3; prostaglandin E synthase 3 (cytosolic); prostaglandin-E synthase 3; Ptges; PTGES3; ptges3 {ECO:0000250; RGD1561913; sid 3177; Sid3177; Tebp; telomerase binding protein, p23; telomerase-binding protein p23; unactive progesterone receptor, 23 kD; UniProtKB:Q15185}
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
10728, 362809, 56351
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
ELISA, Immunohistochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
P83868, Q15185, Q9R0Q7
Gene Symbols
Ptges3
Immunogen
Synthesized peptide derived from human p23 around the phosphorylation site of S113.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- This antibody is predicted to react with human and rat based on sequence homology
- Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone
- Prior to activation, steroid receptors associate with a number of different proteins in both a stable and transient fashion
- Steroid receptor complex proteins include heat shock proteins (HSP70 and HSP90), immunosuppressant binding proteins called immunophilins (the FK506 binding proteins, FKBP52 & FKBP54 and the cyclosporin binding protein, CyP-40) and at least three other proteins termed p23, p60 and p48
- p23 along with HSP70, HSP90 and p60, combine with progesterone receptor (PR) as members of a transient intermediate complex
- Cloned human p23 encodes a protein of 160 amino acids that is highly conserved between species and shows no homology to previously identified proteins
- p23 is a highly acidic phosphoprotein with an aspartic acid-rich C-terminal domain and multiple potential phosphorylation sites
- In vitro studies have suggested that p23 binds to HSP90 and is necessary for the binding of HSP90 and CyP-40 to PR
- While neither its exact function nor mechanism of action have been identified, p23 appears to be an important factor in PR function.