Phospho-MER/SKY (Tyr749, Tyr681) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA540270-Each-of-1 | In Stock | ₹ 46,947.50 |
PA540270 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,947.50
GST (18%): ₹ 8,450.55
Total Price: ₹ 55,398.05
Antigen
Phospho-MER/SKY (Tyr749, Tyr681)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
MERTK
Gene Alias
AI323366; Brt; Bruton agammaglobulinemia tyrosine kinase; BYK; c-Eyk; c-mer; c-mer proto-oncogene tyrosine kinase; Dtk; EC 2.7.10.2; Etk-2; etk2/tyro3; Eyk; kinase Syk; KSYK; Mer; MER proto-oncogene, tyrosine kinase; MER receptor tyrosine kinase; MERTK; nmf12; Nyk; Proto-oncogene c-Mer; proto-oncogene tyrosine-protein kinase MER; rdy; Receptor tyrosine kinase MerTK; Receptor tyrosine tinase gene probably the gene for Rdy; Rek; retinal dystrophy; RP38; RSE; Sky; sMER; sMERTK; soluble MER; soluble MERTK; STK kinase; SYK; Tif; TK19-2; Tyro 12; Tyro12; Tyro3; TYRO3 protein tyrosine kinase; TYRO3 protein tyrosine kinase 3; tyrosine-protein kinase byk; Tyrosine-protein kinase DTK; tyrosine-protein kinase Mer; Tyrosine-protein kinase receptor TYRO3; tyrosine-protein kinase RSE; Tyrosine-protein kinase SKY; tyrosine-protein kinase TIF
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
10461, 17289, 22174, 25232, 65037, 7301
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
ELISA, Immunohistochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
P55144, P55146, P57097, Q06418, Q12866, Q60805
Gene Symbols
MERTK, TYRO3
Immunogen
Synthesized peptide derived from human MerTK/Tyro3 around the phosphorylation site of Y749/681.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- This antibody is predicted to react with mouse and rat based on sequence homology
- Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6
- Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis)
- Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules
- Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1
- MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment
- Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis
- Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.