PSTPIP1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA548384-Each-of-1 | In Stock | ₹ 48,104.50 |
PA548384 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,104.50
GST (18%): ₹ 8,658.81
Total Price: ₹ 56,763.31
Antigen
PSTPIP1
Classification
Polyclonal
Formulation
PBS with 0.09% sodium azide
Gene Accession No.
O43586
Gene Symbols
PSTPIP1
Immunogen
KLH conjugated synthetic peptide between 89-118 amino acids from the N-terminal region of human PSTPIP1.
Quantity
400 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Western Blot
Conjugate
Unconjugated
Gene
PSTPIP1
Gene Alias
CD2 antigen-binding protein 1; CD2 cytoplasmic tail-binding protein; CD2-binding protein 1; CD2BP1; CD2BP1L; CD2BP1S; def-2; H-PIP; PAPAS; PEST phosphatase-interacting protein 1; proline-serine-threonine phosphatase interacting protein 1; proline-serine-threonine phosphatase-interacting protein 1; PSTPIP; Pstpip1; truncated proline-serine-threonine phosphatase interacting protein 1
Host Species
Rabbit
Purification Method
Antigen affinity chromatography, Protein A
Regulatory Status
RUO
Gene ID (Entrez)
9051
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- Predicted to react with mouse based on sequence homology
- PSTPIP1 is involved in regulation of the actin cytoskeleton
- May regulate WAS actin-bundling activity
- Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation
- May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS
- Has the potential to physically couple CD2 and CD2AP to WAS
- Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation
- Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2
- Also has a role in innate immunity and the inflammatory response
- Recruited to inflammasomes by MEFV
- Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis
- Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation
- Regulates endocytosis and cell migration in neutrophils.