PA550194
BCL2L15 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA550194-Each-of-1 | In Stock | ₹ 46,502.50 |
PA550194 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
BCL2L15
Classification
Polyclonal
Conjugate
Unconjugated
Gene
BCL2L15
Gene Alias
BCL2 like 15; BCL2L15; bcl2-L-15; BCL2-like 15; bcl-2-like protein 15; BCLl2-like 15; Bfk; C1orf178; Gm566; pro-apoptotic Bcl-2 protein; RGD1562344
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
440603
Content And Storage
-20°C
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
1.4 mg/mL
Formulation
PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.
Q5TBC7
Gene Symbols
BCL2L15
Immunogen
Fusion protein corresponding to a region derived from internal residues of human BCL2-like 15
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- The antibody detects endogenous levels of total BCL2L15 protein
- Proteins of the Bcl-2 family are critical regulators of apoptosis
- Proapoptotic members, like Bax, contain three of the four Bcl-2 homology regions (BH1-3), while BH3-only proteins, like Bim, possess only the short BH3 motif
- Database searches revealed Bfk, an unusual novel member of the Bcl-2 family that contains a BH2 and BH3 region but not BH1 or BH4
- Bfk is thus most closely related to Bcl-G(L)
- It lacks a C-terminal membrane anchor and is cytosolic
- Enforced expression of Bfk weakly promoted apoptosis and antagonized Bcl-2's prosurvival function
- Like Bcl-G(L), Bfk did not bind to any Bcl-2 family members, even though its BH3 motif can mediate association with prosurvival proteins
- Low amounts of Bfk were found in stomach, ovary, bone marrow and spleen, but its level in the mammary gland rose markedly during pregnancy, suggesting that Bfk may play a role in mammary development.