CARD14 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA550370-Each-of-1 | In Stock | ₹ 47,036.50 |
PA550370 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,036.50
GST (18%): ₹ 8,466.57
Total Price: ₹ 55,503.07
Antigen
CARD14
Classification
Polyclonal
Conjugate
Unconjugated
Gene
CARD14
Gene Alias
Bcl10-interacting MAGUK protein 2; BIMP2; Card14; CARD-containing MAGUK protein 2; Carma 2; CARMA2; caspase recruitment domain family member 14; caspase recruitment domain family, member 14; caspase recruitment domain-containing protein 14; PRP; PSORS2; PSS1
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
79092
Content And Storage
-20°C
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
1.3 mg/mL
Formulation
PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.
Q9BXL6
Gene Symbols
CARD14
Immunogen
Fusion protein corresponding to a region derived from internal residues of human caspase recruitment domain family, member 14
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- The antibody detects endogenous levels of total CARD14 / CARMA2 protein
- Membrane-associated guanylate kinase (MAGUK) family members localize to the plasma membrane and function as molecular scaffolds for the assembly of multi-protein complexes
- The MAGUK family includes several mammalian proteins related to the Drosophila tumor suppressor discs-large (dlg) gene product, such as postsynaptic proteins, GKAPs, the tight junction associated proteins (ZO-1-3) and the caspase-associated recruitment domain (CARD) proteins: CARD 6, CARD 8-12 and CARD 14
- CARD 14 is a 1,004 amino acid protein consisting of an N-terminal CARD domain, a central coiled-coil domain and a C-terminal tripartite domain comprised of a PDZ domain, an Src homology 3 domain and a GUK domain with homology to guanylate kinase
- CARD 14 is expressed in the placenta where it positively regulates apoptosis
- CARD 14 also controls NF-kappaB activation by phosphorylating BCL10, a signaling protein that activates NF-kappaB through the I kappaB kinase complex
- Epigallocatechin-3-gallate (EGCG) is a polyphenol that induces the expression of CARD 14.