NDUFAF2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA550452-Each-of-1 | In Stock | ₹ 48,104.50 |
PA550452 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,104.50
GST (18%): ₹ 8,658.81
Total Price: ₹ 56,763.31
Antigen
NDUFAF2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Ndufaf2
Gene Alias
1810058I14Rik; B17.2L; B17.2-like; B172L; B172-like; C86051; mimitin; mimitin, mitochondrial; MMTN; Myc-induced mitochondria protein; Myc-induced mitochondrial protein; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2; NADH dehydrogenase (ubiquinone) complex I, assembly factor 2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2; NADH dehydrogenase 1 alpha subcomplex assembly factor 2; NADH:ubiquinone oxidoreductase complex assembly factor 2; NDUFA12L; NDUFA12-like protein; Ndufaf2; RGD1560158
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
91942
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
2.6 mg/mL
Formulation
PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.
Q8N183
Gene Symbols
Ndufaf2
Immunogen
Fusion protein corresponding to a region derived from internal residues of human NADH dehydrogenase (ubiquinone) complex I, assembly factor 2
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- The antibody detects endogenous levels of total NDUFAF2 protein
- Mimitin, a small mitochondrial protein, whose transcription is directly stimulated by c-Myc, is highly expressed in 80% of esophageal squamous cell carcinomas (ESCC)
- Suppression of Mimitin expression by RNA interference had no effect in cancerous cell lines such as human cervical carcinoma or hepatocarcinoma cell lines, but caused a decrease in cell proliferation in human glioblastoma, embryonic lung fibroblastic cells, and ESCC, suggesting Mimitin may play a special role in these types of cells
- Mimitin expression is also regulated by MAPK kinases and IL-1, but not through the NF-kappa-B-related pathway
- It will interact with the microtubular protein MAP1S and can affect the activities of caspase-3 and -7 in cells stimulated to develop apoptosis
- Other experiments suggest that Mimitin also acts as a molecular chaperone for the assembly of the mitochondrial complex I.