HSD11B2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA550682-Each-of-1 | In Stock | ₹ 48,104.50 |
PA550682 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,104.50
GST (18%): ₹ 8,658.81
Total Price: ₹ 56,763.31
Antigen
HSD11B2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
HSD11B2
Gene Alias
11(beta)-HSD2; 11-beta-HSD; 11-beta-HSD type II; 11-beta-HSD2; 11-beta-hydroxysteroid dehydrogenase type 2; 11-beta-hydroxysteroid dehydrogenase type II; 11-DH2; 11-HSD type II; 11HSD2; AME; AME1; corticosteroid 11-beta-dehydrogenase isozyme 2; -HSD11 type II; HSD11B2; HSD11K; HSD2; hydroxysteroid (11-beta) dehydrogenase 2; hydroxysteroid 11-beta dehydrogenase 2; Hydroxysteroid dehydrogenase, 11 beta type 2; NAD-dependent 11-beta-hydroxysteroid dehydrogenase; SDR9C3; Short chain dehydrogenase/reductase family 9C member 3
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
3291
Content And Storage
-20°C
Form
Liquid
Applications
Immunohistochemistry (Paraffin)
Concentration
2.9 mg/mL
Formulation
PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.
P80365
Gene Symbols
HSD11B2
Immunogen
Synthetic peptide corresponding to a region derived from internal residues of human hydroxysteroid (11-beta) dehydrogenase 2
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- The antibody detects endogenous levels of total HSD11B2 protein
- There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone
- The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities
- The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity
- In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor
- In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development
- Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.