RRAS Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA550746-Each-of-1 | In Stock | ₹ 47,036.50 |
PA550746 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,036.50
GST (18%): ₹ 8,466.57
Total Price: ₹ 55,503.07
Antigen
RRAS
Classification
Polyclonal
Conjugate
Unconjugated
Gene
RRAS
Gene Alias
AI573426; Harvey rat sarcoma oncogene, subgroup R; Harvey rat sarcoma virus oncogene, subgroup R; oncogene RRAS; p23; ras family small GTP binding protein R-Ras; ras-related protein R-Ras; Ras-related protein R-RAS (P23); related RAS viral (r-ras) oncogene homolog; RRAS
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
20130, 361568, 6237
Content And Storage
-20°C
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
1.9 mg/mL
Formulation
PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.
D3Z8L7, P10301, P10833
Gene Symbols
RRAS
Immunogen
Synthetic peptide corresponding to residues near the N terminal of human related RAS viral (r-ras) oncogene homolog
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- The antibody detects endogenous levels of total RRA S protein
- The Ras superfamily of small GTPases includes the Ras, Rho, Arf, Rab, and Ran families
- Ras-regulated signal pathways control such as actin cytoskeletal integrity, proliferation, differentiation, cell adhesion, apoptosis, and cell migration
- These GTPases function as molecular switches that control eukaryotic cell function by cycling between two interconvertible forms, a GDP-bound inactive form and a GTP-bound active form
- The binding of GTP leads to a conformational change in the downstream effector-binding domain of the G-protein
- The small GTPases are monomeric G-proteins with molecular masses over the range 20-30 kDa
- Ras is attached to the cell membrane by prenylation
- Mutations in the Ras family of proto-oncogenes (comprising H-Ras, N-Ras and K-Ras) are very common, being found in 20% to 30% of all human tumours
- The frequency of RAS mutations is among the highest for any gene in human cancer
- K-ras mutations occur frequently in non-small-cell lung, colorectal, and pancreatic carcinomas; H-ras mutations are common in bladder, kidney, and thyroid carcinomas; N-ras mutations are found in melanoma, hepatocellular carcinoma, and hematologic malignancies.