Phospho-STAT6 (Tyr641) Recombinant Rabbit Monoclonal Antibody (46H1L12), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PI700247-Each-of-1 | In Stock | ₹ 57,093.50 |
PI700247 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 57,093.50
GST (18%): ₹ 10,276.83
Total Price: ₹ 67,370.33
Antigen
Phospho-STAT6 (Tyr641)
Classification
Recombinant Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide
Gene Accession No.
P42226, P52633
Gene Symbols
STAT6
Immunogen
A peptide corresponding to amino acids 636-645 of P42226.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Applications
ChIP Assay, ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone
46H1L12
Conjugate
Unconjugated
Gene
STAT6
Gene Alias
12S1644; D12S1644; IL4 STAT; IL-4 Stat; IL-4-STAT; signal transducer and activator of transcription 6; signal transducer and activator of transcription 6, interleukin-4 induced; signal transducer and transcription activator 6; STAT; STAT, interleukin4-induced; Stat6; STAT-6; STAT6B; STAT6C; transcription factor IL-4 STAT
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
20852, 6778
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
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Description
- This antibody is predicted to react with Rhesus monkey, orangutan, bovine, canine, mouse and rat based on sequence homology
- Intact IgG appears on a non-reducing gel as ∽150 kDa band and upon reduction generating a ∽25 kDa light chain band and a ∽50 kDa heavy chain
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- STAT6 protein is a transcription factor activated by cytokines, particularly interleukin-4 and IL13
- (Stat6-/-) were found to be deficient in IL-4-mediated functions including Th2 helper T-cell differentiation, expression of cell surface markers, T-cell proliferation, immunoglobulin class switching to IgE, and partial loss of IL-4 mediated proliferation
- STAT6 mRNA has been detected in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung and placenta
- STAT6 is critically involved in Th2 immune response
- STAT6 is crucial for IL-4-mediated biological responses, and naturally in two isoforms: STAT6a and STAT6c.