Phospho-STAT5 alpha (Tyr694) Recombinant Polyclonal Antibody (6HCLC), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PI710094-Each-of-1 | In Stock | ₹ 55,981.00 |
PI710094 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 55,981.00
GST (18%): ₹ 10,076.58
Total Price: ₹ 66,057.58
Antigen
Phospho-STAT5 alpha (Tyr694)
Classification
Recombinant Polyclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide
Gene Accession No.
P42229
Gene Symbols
STAT5A
Immunogen
Peptide corresponding to amino acids 688–698 of human STAT5 alpha
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
ChIP Assay, Immunohistochemistry (Paraffin), Western Blot
Clone
6HCLC
Conjugate
Unconjugated
Gene
STAT5A
Gene Alias
AA959963; mammary gland factor; mammary gland factor STAT5A; mammary gland factor; transcription factor; Mgf; Mpf; signal transducer and activator of transcription 5; signal transducer and activator of transcription 5a; signal transducer and activator of transcription factor 5A; STAT; STAT5; STAT5A; STAT5A, Mammary Gland Factor; STAT5A/MGF; STAT5B; STATA5
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
6776
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- This antibody is predicted to react with mouse, rat and non-human primate based on sequence homology
- Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific
- They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody
- While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains
- The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production
- STAT5 alpha is a member of the STAT family of transcription factors
- In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators
- STAT5 alpha is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones
- Activation of STAT5 alpha in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis
- The mouse counterpart of STAT5 alpha is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this protein in cells
- STAT5 alpha, along with STAT5 beta, were identified in mouse
- The amino acid sequences of STAT5 alpha and STAT5 beta show 96% sequence similarity, and both proteins are co expressed in most tissues in virgin and lactating mice
- However, differential accumulation of STAT5 alpha and STAT5 beta mRNA has been reported for both muscle and mammary tissue
- STAT5 alpha is critically involved in a variety of physiological functions, including reproduction, lactation, immune function and somatic growth.