CCL5 (RANTES) Recombinant Rabbit Monoclonal Antibody (25H14L17), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PI701030-Each-of-1 | In Stock | ₹ 51,798.00 |
PI701030 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 51,798.00
GST (18%): ₹ 9,323.64
Total Price: ₹ 61,121.64
Antigen
CCL5 (RANTES)
Classification
Recombinant Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide
Gene Accession No.
P13501, P30882, P50231
Gene Symbols
CCL5
Immunogen
proprietary
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
25H14L17
Conjugate
Unconjugated
Gene
CCL5
Gene Alias
beta-chemokine RANTES; CC chemokine; C-C motif chemokine 5; C-C motif chemokine ligand 5; CCL5; chemokine (C-C motif) ligand 5; D17S136E; EoCP; eosinophil chemotactic cytokine; MGC17164; MuRantes; OTTHUMP00000197106; RANTES; RANTES protein; RANTES(3-68); RANTES(4-68); regulated upon activation normal T-cell expressed and secreted; regulated upon activation, normally T-expressed, and presumably secreted; Scya5; SIS d; SISd; SIS-delta; SISd; small inducible cytokine A5; small inducible cytokine subfamily A (Cys-Cys), member 5; small-inducible cytokine A5; T cell-specific protein P228; T-cell specific protein p288; T-cell-specific protein RANTES; TCP228; Unknown (protein for MGC:127014)
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
20304, 6352, 81780
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- This antibody is predicted to react with human and rat based on sequence homology
- Intact IgG appears on a non-reducing gel as ∽150 kDa band and upon reduction generating a ∽25 kDa light chain band and a ∽50 kDa heavy chain
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- CCL5 (RANTES) is a chemokine gene located on the q-arm of chromosome 17
- Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes
- The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide
- CCL5, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells, and eosinophils
- It causes the release of histamine from basophils and activates eosinophils
- This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells
- It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor
- Alternative splicing results in multiple transcript variants that encode different isoforms
- Diseases associated with CCL5 include Human Immunodeficiency Virus Type 1 and Periapical Granuloma.