Insulin Recombinant Rabbit Monoclonal Antibody (19H4L12), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PI701265-Each-of-1 | In Stock | ₹ 48,816.50 |
PI701265 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,816.50
GST (18%): ₹ 8,786.97
Total Price: ₹ 57,603.47
Antigen
Insulin
Classification
Recombinant Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide
Gene Accession No.
P01308
Gene Symbols
INS
Immunogen
proprietary
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Immunohistochemistry
Clone
19H4L12
Conjugate
Unconjugated
Gene
INS
Gene Alias
AA986540; IDDM; IDDM1; IDDM2; ILPR; INS; Ins1; Ins-1; Ins2; Ins-2; Ins2-rs1; InsII; Insulin; insulin 1; insulin 2; Insulin A chain; Insulin B chain; insulin I; insulin II; insulin-1; Insulin-1 A chain; Insulin-1 B chain; Insulin-2; Insulin-2 A chain; Insulin-2 B chain; IRDN; Mody; MODY10; Mody4; preproinsulin; proinsulin
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
3630
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
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Description
- Intact IgG appears on a non-reducing gel as ∽150 kDa band and upon reduction generating a ∽25 kDa light chain band and a ∽50 kDa heavy chain
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- Insulin is a peptide hormone secreted by beta cells of the pancreatic islets
- It regulates carbohydrate, protein and lipid metabolism by enhancing membrane transport of glucose, amino acids, and certain ions
- It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids
- Insulin is 51-amino acid polypeptide product produced from a precursor peptide, proinsulin
- Proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds and one molecule of C-peptide
- Insulin deficiency results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population
- Insulin is also present in tumors of b-cell origin such as insulinoma.