PIMA516229
IL-17F Monoclonal Antibody (4H1629), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA516229-Each-of-1 | In Stock | ₹ 49,973.50 |
PIMA516229 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,973.50
GST (18%): ₹ 8,995.23
Total Price: ₹ 58,968.73
Antigen
IL-17F
Classification
Monoclonal
Concentration
1.0 mg/mL
Formulation
PBS with 0.05% sodium azide
Gene Accession No.
Q96PD4
Gene Symbols
IL17F
Immunogen
full-length recombinant IL17F
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1 κ
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
4H1629
Conjugate
Unconjugated
Gene
IL17F
Gene Alias
C87042; CANDF6; cytokine ML-1; IL17F; IL-17F; IL-24; ILN; Interleukin; interleukin 17F; Interleukin17F; interleukin-17F; interleukin-24; ML1; ML-1; mutant IL-17F
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
112744
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- IL-17F (Interleukin 17F, CTLA-8)) is a cytokine belonging to the IL-17 family that is produced by inflammatory cells such as activated T cells, mast cells, and basophils
- IL-17F is involved in allergic airway inflammation, and can induce several cytokines, chemokines, and adhesion molecules in bronchial epithelial cells, vein endothelial cells, fibroblasts, and eosinophils
- IL-17F may be secreted as a homodimer, or a heterodimer with IL17A
- It acts by binding to the type I receptor, IL-17R, aiding recruitment of monocytes and neutrophils at the site of inflammation by increasing chemokine production
- IL-17F also stimulates induction of other pro-inflammatory cytokines TNF alpha, IL-1 beta, IL-6, and IL-8, and reports strongly suggest the involvement of IL-17 in several chronic inflammatory diseases such as rheumatoid arthritis, psoriasis and multiple sclerosis
- TGF-beta (differentiation) and IL-23 (expansion) are required for induction and maintenance of Th17 (IL-17 producing) cells, which in turn induce the other pro-inflammatory cytokines
- IL-17F is produced, and exists, as a homo-dimer, with homology to a herpes virus early protein, is one of the six members (IL-17A-F) of this cytokine family, and is well characterized and highly expressed by activated effector memory T cells
- IL-17F has been found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1.