FGF2 Recombinant Polyclonal Antibody (7HCLC), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PI710148-Each-of-1 | In Stock | ₹ 50,596.50 |
PI710148 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,596.50
GST (18%): ₹ 9,107.37
Total Price: ₹ 59,703.87
Antigen
FGF2
Classification
Recombinant Polyclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide
Gene Accession No.
P09038
Gene Symbols
FGF2
Immunogen
Recombinant protein corresponding to amino acids 163–285 of human FGF2 (basic)
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Western Blot
Clone
7HCLC
Conjugate
Unconjugated
Gene
FGF2
Gene Alias
Basic fibroblast growth factor; basic fibroblast growth factor bFGF; bFGF; FGF; fgf basic; Fgf2; Fgf-2; Fgfb; FGF-b; Fibroblast growth factor; fibroblast growth factor 2; fibroblast growth factor 2 (basic); HBGF-2; Heparin-binding growth factor 2; H-FGF-b-147; H-FGF-b-154; M-FGF-b; Prostatic growth factor; prostatropin
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
2247
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific
- They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody
- While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains
- The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production
- FGF2 (FGFb, fibroblast growth factor basic) belongs to the fibroblast growth factor (FGF) family, and interacts with high-affinity transmembrane receptors to influence cell proliferation and tissue neovascularization
- FGF2 exists as five isoforms with distinct intracellular localizations and functions
- The 18 kDa isoform is predominantly cytosolic and acts through cell surface receptors, whereas the 22, 22.5, 24 and 34 kDa isoforms are nuclear and may signal independent of transmembrane receptor pathways
- In humans, the gene is located on the q arm of chromosome 4
- FGF2 has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth
- The mRNA for FGF2 contains multiple polyadenylation sites, and is alternatively translated from non-AUG and AUG initiation codons, resulting in five different isoforms with distinct properties
- The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF
- Diseases associated with FGF2 dysfunction include Kaposi Sarcoma and corneal neovascularization.