Bacillus anthracis Spore Antigen Monoclonal Antibody (SA26), Invitrogen™

Description

• MA1-21719 detects Bacillus anthracis spore antigen in Bacteria samples
• Anthrax toxin is a three-protein exotoxin secreted by virulent strains of the bacterium Bacillus anthracis, the causative agent of anthrax
• Anthrax toxin is composed of a cell-binding protein, known as protective antigen (PA), and two enzyme components, called edema factor (EF) and lethal factor (LF)
• These three protein components act together to impart their physiological effects
• Assembled complexes containing the toxin components are endocytosed
• In the endosome, the enzymatic components of the toxin translocate into the cytoplasm of a target cell
• Once in the cytosol, the enzymatic components of the toxin disrupts various immune cell functions, namely cellular signaling and cell migration
• The toxin may even induce cell lysis, as is observed for macrophage cells
• Anthrax toxin allows the bacteria to evade the immune system, proliferate, and μgtimately kill the host animal
• Research on anthrax toxin also provides insight into the generation of macromolecular assemblies, and on protein translocation, pore formation, endocytosis, and other biochemical processes.