PIMA133625
LAIR1 Monoclonal Antibody (NKTA255), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA133625-Each-of-1 | In Stock | ₹ 79,076.50 |
PIMA133625 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 79,076.50
GST (18%): ₹ 14,233.77
Total Price: ₹ 93,310.27
Antigen
LAIR1
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
Q6GTX8
Gene Symbols
LAIR1
Immunogen
NK cells lines B12.100 and AM.25
Quantity
500 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
Flow Cytometry, Immunoprecipitation, Western Blot
Clone
NKTA255
Conjugate
Unconjugated
Gene
LAIR1
Gene Alias
5133400O11Rik; BB115266; CD305; D7Bwg0421e; immunoglobulin heavy chain variable region; Lair1; Lair-1; leukocyte associated immunoglobulin like receptor 1; leukocyte-associated Ig-like receptor 1; leukocyte-associated Ig-like receptor-1; leukocyte-associated immunoglobulin-like receptor 1; rLAIR1
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
3903
Content And Storage
4° C
Form
Liquid
Related Products
Description
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- LAIR1 (CD305) functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells
- Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11
- It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation
- May also play its inhibitory role independently of SH2-containing phosphatases
- Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta
- Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion
- Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells
- Inhibits the differentiation of peripheral blood precursors towards dendritic cells.