I-Ak Monoclonal Antibody (14V.18), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA170068-Each-of-1 | In Stock | ₹ 39,071.00 |
PIMA170068 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 39,071.00
GST (18%): ₹ 7,032.78
Total Price: ₹ 46,103.78
Antigen
I-Ak
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.02% sodium azide
Gene Accession No.
P01910, P04227, P04228, P14434, P14435, P14436, P14437, P14438, P23150
Gene Symbols
H2-Aa
Immunogen
A.TL.
Quantity
250 μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG2a
Applications
Flow Cytometry
Clone
14V.18
Conjugate
Unconjugated
Gene
H2-Aa
Gene Alias
A alpha; Aalpha; H-2 class II histocompatibility antigen, A-B alpha chain; H-2 class II histocompatibility antigen, A-F alpha chain; H-2 class II histocompatibility antigen, A-K alpha chain; H-2 class II histocompatibility antigen, A-Q alpha chain; H-2 class II histocompatibility antigen, A-R alpha chain; H-2 class II histocompatibility antigen, A-S alpha chain; H-2 class II histocompatibility antigen, A-U alpha chain; H2Aa; H-2Aa; H2-Aa; histocompatibility 2, class II antigen A, alpha; Ia1; Ia-1; IAalpha; I-Aalpha; major histocompatibility protein class II alpha chain; MHC class II antigen A alpha isoform-004; MHC-II I-A(d) alpha
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
14960
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- MA1-70068 detects I-Ak in mouse samples
- MA1-70068 has been successfully used in flow cytometry procedures
- The MA1-70068 immunogen is A.TL
- Store at 4oC
- For long term storage, aliquot and freeze at -20oC, in volumes appropriate for single uses
- Avoid freeze/thaw cycles
- MHC Class II (I-Ak) serves as a critical component of the immune system, facilitating the recognition and response to extracellular pathogens and foreign substances
- Its primary role is to present peptides derived from extracellular proteins to T cells for immune recognition
- MHC Class II (I-Ak) is composed of an alpha and beta chain, both of which contribute to the peptide-binding groove
- The location of MHC Class II (I-Ak) is restricted to antigen-presenting cells, such as dendritic cells, macrophages, and B cells
- These cells are responsible for capturing and processing antigens from the extracellular environment
- MHC Class II (I-Ak) consists of an extracellular domain, a transmembrane domain, and a cytoplasmic tail
- The extracellular domain is responsible for interacting with the antigenic peptides, while the transmembrane domain anchors the MHC Class II molecule to the cell membrane
- The cytoplasmic tail plays a role in intracellular signaling events
- HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.