CD81 Monoclonal Antibody (1.3.3.22), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA513548-Each-of-1 | In Stock | ₹ 52,332.00 |
PIMA513548 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,332.00
GST (18%): ₹ 9,419.76
Total Price: ₹ 61,751.76
Antigen
CD81
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with 0.05% BSA and 0.05% sodium azide; pH 7.4
Gene Accession No.
P60033, Q62745
Gene Symbols
CD81
Immunogen
B cell line derived from a Burkitt lymphoma
Quantity
500 μL
Primary or Secondary
Primary
Target Species
Human, Rat
Product Type
Antibody
Isotype
IgG1 κ
Applications
Flow Cytometry, Functional Assay, Immunocytochemistry, Immunohistochemistry (Frozen), Western Blot
Clone
1.3.3.22
Conjugate
Unconjugated
Gene
CD81
Gene Alias
26 kDa cell surface protein TAPA-1; CD 81 antigen; Cd81; CD81 antigen; CD81 antigen (target of antiproliferative antibody 1); CD81 molecule; CVID6; S5.7; Tapa1; Tapa-1; Target of the antiproliferative antibody 1; Tetraspanin28; tetraspanin-28; Tspan28; Tspan-28
Host Species
Mouse
Purification Method
Protein A/G
Regulatory Status
RUO
Gene ID (Entrez)
25621, 975
Content And Storage
4° C
Form
Liquid
Related Products
Description
- MA5-13548 targets CD81 in WB, FACS, FN, ICC/IF, and IHC (F) applications and shows reactivity with Human and Rat samples
- The MA5-13548 immunogen is b cell line derived from a Burkitt lymphoma
- CD81 (TAPA-1, target of anti-proliferative antibody-1) is a member of the tetraspanin family, is expressed on virtually all nucleated cells, but above all on germinal center B cells
- CD81 forms complexes with other tetraspanin proteins, integrins, coreceptors, MHC class I and II molecules, and influences adhesion, morphology, activation, proliferation and differentiation of B, T cells
- In muscles, CD81 promotes cell fusion and myotube maintenance
- CD81 has been also identified as a receptor for the hepatitis C virus
- Like members of the tetraspanin family that include CD9, CD37, CD53, CD63, and CD82, CD81 is a cell-surface proteins that are characterized by the presence of four hydrophobic domains
- The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility
- CD81 is a cell surface glycoprotein that is known to complex with integrins
- CD81 appears to promote muscle cell fusion and support myotube maintenance
- CD81 associates with CD19, CD21, Leu 13, and integrins on cell membrane and acts as a receptor for the envelope protein E2 of chronic hepatitis C virus
- Antibodies to CD81 have anti-proliferative effects on different lymphoid cell lines, particularly those derived from large cell lymphomas
- CD81 is also localized in the tumor-suppressor gene region and is a candidate gene for malignancies.