SMAD4 Monoclonal Antibody (SMD46 (DCS-46)), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA514300-Each-of-1 | In Stock | ₹ 52,109.50 |
PIMA514300 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,109.50
GST (18%): ₹ 9,379.71
Total Price: ₹ 61,489.21
Antigen
SMAD4
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Gene Accession No.
Q13485
Gene Symbols
SMAD4
Immunogen
Purified recombinant DPC4 protein
Quantity
500 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
Immunocytochemistry, Immunoprecipitation, Western Blot
Clone
SMD46 (DCS-46)
Conjugate
Unconjugated
Gene
SMAD4
Gene Alias
AW743858; D18Wsu70e; Deleted in Pancreatic Carcinoma 4 (DPC4); deleted in pancreatic carcinoma locus 4; deletion target in pancreatic carcinoma 4; Deletion target in pancreatic carcinoma 4 homolog; DPC4; hSMAD4; JIP; MAD (mothers against decapentaplegic Drosophila) homolog 4; MAD homolog 4; MAD homolog 4 (MADH4); Madh4; mothers against decapentaplegic homolog 4; Mothers against decapentaplegic homolog 4 (MADH4); mothers against decapentaplegic, Drosophila, homolog of, 4; mothers against DPP homolog 4; MYHRS; SMAD; SMAD 4; SMAD family member 4; SMAD, mothers against DPP homolog 4; SMAD4
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
4089
Content And Storage
4° C
Form
Liquid
Related Products
Description
- MA5-14300 targets SMAD4 in IF, IP, and WB applications and shows reactivity with Human samples
- The MA5-14300 immunogen is purified recombinant DPC4 protein
- Smad4 is encoded by the Smad4 gene that is located on chromosome 18 in humans
- Smad4 is also known as Smad family member 4, Sma- and Mad-related protein 4 or Mothers against decapentaplegic (MAD) homolog 4
- Smad4 contains N-terminal MH1 (MAD homology 1) and C-terminal MH2 (MAD homology 2) globular domains that are involved in DNA binding and protein interactions respectively
- Binding of the TGF-beta superfamily of ligands that includes Transforming Growth Factor -beta (TGF-beta) and bone morphogenetic protein (BMP) to its cognate receptor allows phosphorylation of Smad 1, 2, 3, 5 and 8 (R-Smad, Receptor Smad)
- This signals for heterotrimerization with Smad4 (co-Smad, co-mediator Smad) and translocation of the complex to the nucleus
- Inhibitory or antagonistic Smad (I-Smad) that includes Smad 6 and 7, interact with activated R-Smads and attenuate the signaling pathway
- Smad4 acts as a tumor suppressor protein by transcriptionally regulating its target genes such as Cyclin D1 (downregulation) and collagen (upregulation) that inhibit cell proliferation
- Dephosphorylation regulates nuclear export and nucleocytoplasmic dynamics of Smads.