ALK Monoclonal Antibody (SP8), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA514528-Each-of-1 | In Stock | ₹ 55,625.00 |
PIMA514528 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 55,625.00
GST (18%): ₹ 10,012.50
Total Price: ₹ 65,637.50
Antigen
ALK
Classification
Monoclonal
Concentration
Conc. Not Determined
Formulation
tissue culture supernatant diluted in TBS with 1% BSA and 0.1% sodium azide; pH 7.5
Gene Accession No.
P97793, Q9UM73
Gene Symbols
ALK
Immunogen
Recombinant protein corresponding to a region, which spans the tyrosine kinase catalytic domain and part of the C-terminus of the NPM-ALK transcript
Regulatory Status
RUO
Gene ID (Entrez)
11682, 238
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin)
Clone
SP8
Conjugate
Unconjugated
Gene
ALK
Gene Alias
Alk; ALK tyrosine kinase receptor; ALK/NPM1 fusion gene; anaplastic lymphoma kinase; Anaplastic lymphoma kinase Ki1; Anaplastic Lymphoma Kinase p80; anaplastic lymphoma receptor tyrosine kinase; CD246; CD246 antigen; EC 2.7.10.1; kinase ALK; mutant anaplastic lymphoma kinase; NBLST3; npm-alk; p80; Tcrz; TFG/ALK
Host Species
Rabbit
Quantity
500 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- MA5-14528 targets ALK (Anaplastic Lymphoma Kinase) / p80 in IHC (P) and ICC/IF applications and shows reactivity with Human and Mouse samples
- The MA5-14528 immunogen is recombinant protein corresponding to a region, which spans the tyrosine kinase catalytic domain and part of the C-terminus of the NPM-ALK transcript
- Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily
- It is vital for brain development
- Mutations, rearrangements, and amplifications in the ALK gene have been found in tumors, including anaplastic large cell lymphoma, neurblastoma, and non-small cell lung cancer
- Chromosomal rearrangement is the most common genetic alteration
- The translocation creates a fusion gene consisting of the ALK gene and the nucleophosmin gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5
- A recent study shows that the product of the NPM-ALK fusion gene is oncogenic
- The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain
- These sequences are absent in the product of the transforming NPM-ALK gene
- ALK shows the greatest sequence similarity to LTK
- ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system.