Phospho-PDPK1 (Ser241) Monoclonal Antibody (K.424.2), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA514780-Each-of-1 | In Stock | ₹ 48,015.50 |
PIMA514780 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,015.50
GST (18%): ₹ 8,642.79
Total Price: ₹ 56,658.29
Antigen
Phospho-PDPK1 (Ser241)
Classification
Monoclonal
Concentration
62 μg/mL
Formulation
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5
Gene Accession No.
O15530, O55173, Q9Z2A0
Gene Symbols
Pdpk1
Immunogen
Synthetic phosphopeptide corresponding to residues around pSer241 of human PDK1
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunoprecipitation, Western Blot
Clone
K.424.2
Conjugate
Unconjugated
Gene
Pdpk1
Gene Alias
3-phosphoinositide dependent protein kinase 1; 3-phosphoinositide dependent protein kinase-1; 3-phosphoinositide-dependent protein kinase 1; 3-phosphoinositide-dependent protein kinase 2 pseudogene; HGNC:8809; hPDK1; isoenzyme 1; kinase isoenzyme 1; lipoamide; mPDK1; OTTHUMP00000174525; OTTHUMP00000205076; PDK1; PDPK1; PDPK2; PDPK2P; Pkb kinase; PkB kinase like gene 1; PkB-like 1; PRO0461; Protein kinase B kinase
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
18607, 5170, 81745
Content And Storage
-20°C
Form
Liquid
Related Products
Description
- It is not recommended to aliquot this antibody
- PDPK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases
- PDPK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop
- PDPK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate
- Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase, and the stimulation of glycogen synthesis
- Because of the role that PDPK1 plays in insulin-induced glycogen synthesis and PKC activation, it is a potentially important target for metabolic drug research.